Publications by authors named "Magdalena Drobna"
Article Synopsis
- The study explored how perivascular adipose tissue (PVAT) interacts with endogenous and exogenous hydrogen sulfide (HS) in the thoracic aorta of normotensive and hypertensive rats.
- In spontaneously hypertensive rats (SHRs), PVAT exhibited an anticontractile effect but also negatively impacted endothelial-dependent vasorelaxation, while HS had mixed effects on vasorelaxation depending on the rat strain.
- Overall, the findings suggest PVAT may aggravate endothelial function in SHRs, but HS from the vascular wall promotes relaxation, indicating a potential compensatory mechanism for regulating vascular tone.
Article Synopsis
- This study examined how chronic hydrogen sulfide (HS) inhibition and acute nitric oxide (NO) deficiency affect blood pressure responses in arteries, both in live subjects and in isolated arteries in lab settings.* -
- Chronic HS inhibition did not noticeably impact blood pressure or heart health but caused renal hypertrophy and changes in vascular responses, while acute HS deficiency increased the basal tone in the mesenteric artery.* -
- The findings suggest that endogenous HS contributes to the availability of endothelial NO in arteries and that when both HS and NO levels drop, alternative compensatory mechanisms help maintain vascular function.*
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1-7 (Ang 1-7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies.
View Article and Find Full Text PDFIn this study, we evaluated the effect of eight weeks of administration of 10% fructose solution to adult Wistar Kyoto (WKY) rats on systolic blood pressure (SBP), plasma and biometric parameters, vasoactive properties of the thoracic aorta (TA), NO synthase (NOS) activity, and the expression of enzymes producing NO and HS. Eight weeks of fructose administration did not affect SBP, glycaemia, or the plasma levels of total cholesterol or low-density and high-density lipoprotein; however, it significantly increased the plasma levels of γ-glutamyl transferase and alanine transaminase. Chronic fructose intake deteriorated endothelium-dependent vasorelaxation (EDVR) and increased the sensitivity of adrenergic receptors to noradrenaline.
View Article and Find Full Text PDFWe have investigated the vasoactive effects of the coupled nitro-sulfide signaling pathway in lobar arteries (LAs) isolated from the nephrectomized kidneys of cancer patients: normotensive patients (NT) and patients with arterial hypertension (AH). LAs of patients with AH revealed endothelial dysfunction, which was associated with an increased response to the exogenous NO donor, nitrosoglutathione (GSNO). The interaction of GSNO with the HS donor triggered a specific vasoactive response.
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