PON1 status evaluation in patients with chronic arterial occlusion of lower limbs due to atherosclerosis obliterans.

Introduction: Human paraoxonase (PON1) is a calcium-dependent enzyme physically associated with HDL, and it is believed to contribute to the atheroprotective effect of HDL. The aim of the study was to evaluate PON1 status in patients with atherosclerosis obliterans as an effect of ischemia regarding its activity and phenotype distribution.

Material And Methods: The study group consisted of patients with chronic arterial occlusion of the lower limbs due to atherosclerosis obliterans (AO).