Tricuspid valve maladaptation in sheep with biventricular heart failure: The posterior and septal leaflets.

Tricuspid valve leaflets are dynamic tissues that can remodel in response to altered biomechanical and hemodynamic loads. The anterior, posterior, and septal leaflets exhibit distinct morphology, composition, and mechanical properties, resulting in varying in vivo strains. We hypothesized that these differences would result in leaflet-specific remodeling changes in a sheep model of biventricular heart failure.

Differential gene expression of leaflet tissue in chronic ovine functional tricuspid regurgitation.

Objectives: Severe functional tricuspid regurgitation (FTR) is associated with subvalvular remodelling, but leaflet tissue alterations may also contribute. We set out to investigate molecular mechanisms driving leaflet remodelling in chronic ovine FTR.

Methods: Thirteen adult sheep (55 ± 4kg) underwent left thoracotomy, epicardial echocardiography, and pulmonary artery banding (PAB) to induce right heart failure and FTR.

Sleeping Disorders in Healthy Individuals with Different Dietary Patterns and BMI, Questionnaire Assessment.

The COVID-19 pandemic and abiding restrictions have affected every life domain. Sleep disturbances are a major health issue that is linked with a higher prevalence of metabolic syndrome, obesity, and psychological burdens. Research of sleeping disorders among vegetarian and non-vegetarian subpopulations is limited.

Open aortic arch surgery: 10 years' single-center experience.

Introduction: Open aortic arch surgery is a complex cardiac surgical procedure.

Aim: We reviewed the 10-year outcomes of elective aortic arch aneurysm surgery in a single cardiac surgical center.

Material And Methods: The analysis includes all patients who underwent elective aortic arch surgery at our institution between January 2010 and December 2020.

Assessment of adrenal reserve and secretion of cortisol in patients over 60 years of age undergoing cardiac surgery.

Introduction: Cortisol level affects the prognosis of patients after cardiac surgery. Meanwhile, there are no clear guidelines for steroid supplementation after a cardiac operation. The relationship between age and blood cortisol levels has not been finally clarified.

Can human myocardium be remotely preconditioned? The results of a randomized controlled trial.

Objectives: No experimental study has shown that the myocardium of a remotely preconditioned patient is more resistant to a standardized ischaemic/hypoxic insult.

Methods: This was a single-centre randomized (1:1), double-blinded, sham-controlled, parallel-group study. Patients referred for elective coronary bypass surgery were allocated to either remote ischaemic preconditioning (3 cycles of 5-min ischaemia/5-min reperfusion of the right arm using a blood pressure cuff inflated to 200 mmHg) or sham intervention.

Remote Ischaemic PrEconditioning of Human Myocardium (RIPE): study protocol for a double-blinded randomised controlled trial.

Background: Remote preconditioning has been shown to be a potent protective phenomenon in many animals. Several studies aimed to demonstrate it was feasible in humans by trying to show its protective effect during cardiac surgery. Of these, some small studies and one larger trial were positive while two other bigger studies showed no effectiveness of remote preconditioning as assessed by levels of postoperatively released cardiac markers.

Postoperative serum troponin T concentration in patients undergoing aortic valve replacement does not predict early postoperative outcome.

Background: The measurement of serum cardiac troponin T concentration (cTnT) after aortic valve replacement (AVR) provides the opportunity to assess the degree of myocardial damage and may have some prognostic value.

Aim: To determine whether elevated troponin level is related to patient outcome.

Methods: We investigated patient outcome and postoperative serum concentration of troponin T in 79 patients who underwent AVR.