Publications by authors named "Magda Mareckova"
Article Synopsis
- The Human Endometrial Cell Atlas (HECA) is a comprehensive single-cell reference atlas derived from 313,527 cells, profiling endometrial samples from 63 women, both with and without endometriosis.
- HECA not only categorizes known cell types but also identifies new ones, utilizing advanced techniques like spatial transcriptomics and validation through an independent single-nuclei dataset.
- The findings reveal significant cellular interactions in the endometrium, suggest potential dysregulation of specific cell types in endometriosis, and position HECA as a crucial tool for understanding endometrial health and related disorders.
Females are born with a finite number of oocytes, collectively termed the ovarian reserve, established within the developing fetal ovary. Consequently, maternal exposure to reproductive toxicants can have harmful effects on the future fertility of her unborn female fetus. The chemical benzo[a]pyrene (B[a]P) is a prominent component of cigarette smoke.
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- Gonadal development involves sex determination leading to the maturation of testes or ovaries, but understanding it in humans has been difficult due to limited tissue access and differences with mouse models.
- The researchers created detailed maps of human gonads from the first and second trimesters using advanced techniques like single-cell transcriptomics and fluorescent microscopy to identify key regulatory programs in germline and somatic cell development.
- They pinpointed specific cell types and signaling mechanisms in both males and females, revealing insights into ovarian development and male fetal macrophages, which could inform future in vitro gonadogenesis studies.
The trillions of cells in the human body develop as a result of the fusion of two extremely specialized cells: an oocyte and a sperm. This process is essential for the continuation of our species, as it ensures that parental genetic information is mixed and passed on from generation to generation. In addition to producing oocytes, the female reproductive system must provide the environment for the appropriate development of the fetus until birth.
View Article and Find Full Text PDFMaternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone supplementation would increase fetal progesterone, affect progesterone target tissues in the developing fetal reproductive system and be metabolised to other bioactive steroids in the fetus.
View Article and Find Full Text PDFThe development of therapies promoting recovery after spinal cord injury is a challenge. Alginate hydrogels offer the possibility to develop biocompatible implants with mechanical properties tailored to the nervous tissue, which could provide a permissive environment for tissue repair. Here, the effects of non-functionalized soft calcium alginate hydrogel were investigated in a rat model of thoracic spinal cord hemisection and compared to lesioned untreated controls.
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