Cisplatin dose adjustment in patients with renal impairment, which recommendations should we follow?

Background: Nephrotoxicity is the dose-limiting side effect of cisplatin justifying the assessment of renal function for dose adjustment.

Objective: To determine whether appropriate dose adjustment is made in patients with renal impairment using the Cockcroft-Gault (CG) or the abbreviated Modification of Diet in Renal Disease (aMDRD) formulas to estimate the glomerular filtration rate (GFR).

Setting: The study was conducted in a 1,000-bed university hospital.