Publications by authors named "Magali Maire"
Article Synopsis
- Healthcare professionals are addressing challenges related to drug-related problems (DRPs) in patients undergoing oral anticancer therapy (OAT), including side effects and medication errors.
- The ONCORAL program provides a structured care plan with weekly consultations to help manage these DRPs during the first OAT cycle, involving interventions from nurses and pharmacists.
- Results indicated that 87.1% of patients received interventions, identifying numerous DRPs and leading to adjustments in medications, with an average relative dose intensity of 83.1% for the treatment cycle.
Background In previous studies, patient-reported outcomes (PROs) have been shown to improve survival in cancer patients. The aim of the present study was to assess symptoms potentially related to adverse events experienced by cancer outpatients treated by oral anticancer agents (OAAs) using PROs. Methods Between September 2018 and May 2019, outpatients starting OAAs were included in a 12-week follow-up to assess 15 symptoms listed in the National Cancer Institute PRO Common Terminology Criteria for Adverse Events, using a 5-point scale of severity or frequency.
View Article and Find Full Text PDFCharacterization of the double-stranded RNA responses in human liver progenitor cells.
Biochem Biophys Res Commun
April 2008
Article Synopsis
- Human HepaRG cells, which are liver progenitor cells with characteristics similar to hepatocytes, were studied for their response to double-stranded RNA (dsRNA).
- The research revealed that dsRNA significantly increased the production of chemokines like CXCL10 and IL-8, as well as interferon (IFN)-beta, with certain signaling pathways (like TLR3 and RIG-I) being essential for this response.
- The results indicated that while dsRNA triggers antiviral and pro-inflammatory responses in HepaRG cells, knocking down IFN-beta negates the antiviral effects without promoting HCV RNA replication.
In utero exposure to chemicals with antiandrogen activity induces undescended testis, hypospadias, and sub- or infertility. The hypospermatogenesis observed in the adult rat testis exposed in utero to the antiandrogen flutamide has been reported to be a result of a long-term apoptotic cell death process in mature germ cells. However, little if anything is known about the upstream signaling mechanisms controlling this apoptosis.
View Article and Find Full Text PDFIn the present study we investigated whether fetal exposure to flutamide affected messenger and protein levels of claudin-11, a key Sertoli cell factor in the establishment of the hemotesticular barrier, at the time of two key events of postnatal testis development: 1) before puberty (postnatal d 14) during the establishment of the hemotesticular barrier, and 2) at the adult age (postnatal d 90) at the time of full spermatogenesis. The data obtained show that claudin-11 expression was inhibited in prepubertal rat testes exposed in utero to 2 and 10 mg/kg x d flutamide. However, in adult testes, the inhibition was observed only with 2, and not with 10, mg/kg x d of the antiandrogen.
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