Molecular and Physiological Logics of the Pyruvate-Induced Response of a Novel Transporter in .

At the heart of central carbon metabolism, pyruvate is a pivotal metabolite in all living cells. is able to excrete pyruvate as well as to use it as the sole carbon source. We herein reveal that (renamed ), the only operon specifically induced in pyruvate-grown cells, encodes a hetero-oligomeric membrane complex which operates as a facilitated transport system specific for pyruvate, thereby defining a novel class of transporter.

Translation elicits a growth rate-dependent, genome-wide, differential protein production in Bacillus subtilis.

Complex regulatory programs control cell adaptation to environmental changes by setting condition-specific proteomes. In balanced growth, bacterial protein abundances depend on the dilution rate, transcript abundances and transcript-specific translation efficiencies. We revisited the current theory claiming the invariance of bacterial translation efficiency.