[REGRESSION OF ATHEROSCLECROTIC LESIONS: MEDICAMENTAL AND ALIMENTARY FACTORS].

The article reports results of clinical studies aimed to elucidate the influence of medicines on the size and density of atherosclerotic plaques in the walls of coronary and cerebral arteries. The phenomenon of regression of atherosclerotic lesions in the survivors of Leningrad siege during a long period of starvation is analyzed. The influence of inhibitors of angiotensin-converting enzyme on apoptosis of smooth muscle and foam cells of atherosclerotic plaques in the sanological mechanisms of atherosclerosis is discussed.

[Physiological basis of survival and rehabilitation of the residents of blockaded Leningrad].

The authors attribute survival of certain residents of blockaded Leningrad under conditions ofcomplete starvation to activation of natural sanologic mechanisms of the body. Physiological psychoemotional stress is supposed to contribute to the formation of prerequisites for survival during subsequent starvation. Also, the survival is believed to be related to selected activation of apoptosis of renewable cells and utilization of their constituents in endogenous nutrition.

[Leningrad blockade and its medical implications. Part 2].

Medical consequences of Leningrad blockade are considered from the standpoint of modern science. Pathologies acquired by blockade survivors are regarded as extreme polymorbid conditions caused by combined effect of prolonged psychemotional stress, largest-scale famine, and hypothermia responsible for undermining vital functions. Special emphasis is laid on the role of nervous system dysregulation in the development of many diseases.

[Leningrad blockade and its medical implications. Part 1].

Medical consequences of Leningrad blockade are considered from the standpoint of modern science. Pathologies acquired by blockade survivors are regarded as extreme polymorbid conditions caused by combined effect of prolonged psychemotional stress, largest-scale famine, and hypothermia responsible for undermining vital functions. Special emphasis is laid on the role of nervous system dysregulation in the development of many diseases.

[Serotonin antibodies and their possible role in parkinsonism].

Serotonin antibodies (SAb) were found in the blood sera of middle-aged and elderly parkinsonian patients. The incidence of Sab in young and middle-aged healthy subjects was less, but increasing with age. Injected into the rabbit caudate nuclei, Sab suppressed the main pathogenetic mechanism of parkinsonian syndrome, the generator of pathologically enhanced excitation (GPEE) and parkinsonian symptoms induced by the MPP injection into substantia nigra.

[Role of the striatal serotoninergic apparatus in Parkinsonian syndrome].

Injected into the rat caudate nuclei (CN) serotonin promotes the generator of pathologically enhanced excitation (GPEE) in CN and parkinsonian symptoms, induced by MPP+ injection into substantia nigra. Serotonin antibody injected in CN decreases the GPEE activity and partly suppresses the parkinsonian symptoms. The role of serotoninergic system in parkinsonism is discussed.

[Dopamine antibodies in parkinsonism patients and their possible role in the pathogenesis of the parkinsonian syndrome].

Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor).

[Dopamine antibodies in the pathogenesis of parkinsonism].

L-DOPA and dopamine (DA) binding antibodies were found in the blood serum of Parkinsonian patients and middle-aged and elderly normal persons. DA-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (generator of pathologically enhanced excitation) in these brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity, tremor). The serum gamma-globulins of Parkinsonian patients without Da-antibodies caused less pronounced EEG disturbances.

[Detection of latent spontaneous pathology of the central nervous system and visceral organs in rabbits by determining antibodies to tissue antigens and by a test for delayed hypersensitivity].

Complex immunological, pathologicoanatomic and histopathological examination of intact rabbits revealed a correlation between the appearance of complement fixation antibodies and delayed hypersensitivity to tissue antigens on the one hand and the development of spontaneous pathology of the corresponding organs on the other. Meningoencephalitis was diagnosed in all sick animals by means of immunological tests. Tests for antibodies and delayed hypersensitivity to tissue antigens revealed intracapillary glomerulonephritis, coccidiosis of the liver, and pneumonia.

[EEG changes and symptomatic parkinsonism after intracaudate administration of dopamine antibodies].

Intracaudate bilateral injection of the dopamine antibodies caused the formation of the generator of pathologically enhanced excitation in caudate nuclei. All the rats exhibited the oligokinesia, rigidity and head tremor were observed in most animals. These abnormalities could be observed during 24 hours.

[Structural bases of the induction of immune reactions in emotional stress].

Immobilization stress in rats can provoke damages of the brain parenchymal vessels, which are most pronounced in the reticular formation of the midbrain. In this case the blood plasma and cells enter the brain and the blood elements of brain tissue enter the circulation. Some experimental animals exhibit the serum complement-fixing brain antibodies and specific reactions of basophils to brain antigens 14 days after exposure to stress.

[Autoimmune reactions in experimental pathology of the hippocampus].

Experimental hippocampal pathology caused by the local electrolytic lesion of the dorsal hippocampal area was shown to induce synthesis of antibodies to neurotransmitters (epinephrine and serotonin) and to hippocampal, heart and lung tissue antigens.

[Data on a study of the nature of secondary immunodeficient states. I. An immunophysiological analysis of the mechanisms of allergic reaction suppression in experimental lesion of the structures of the dorsal hippocampus].

Experiments on rabbits demonstrated that local electrocoagulation of the dorsal hyppocampus portions by means of the implanted electrodes caused reduction of the complementary and lysozyme activity of the blood serum, inhibited the development of Arthus' skin allergic-reaction, decreased the intensity of systemic anaphylaxis to the blood serum antigens, this being accompanied by a relative fall of the precipitating antibodies titres and a reduction of the vagus response of the heart to adrenaline.