[The resonance EEG reactions in rhythmical photostimulation and the changes in functional status].

Changes in EEG fine structure in the occipital areas, heart rate, and breath pattern were recorded in 10 male volunteers under photic stimulation with slowly varying frequency in the range of lower or higher EEG alpha-subbands. Self-ratings (on the scale SAN-self-assessment of state of health, activity, and mood) of the functional state, general activity, and mood were obtained before and after stimulation. EEG effects of such photostimulation were represented by the resonance EEG responses of discrete spectral EEG components, frequencies of which periodically coincided with varying rate of flashes.

[The circadian phototherapy of bronchial asthma].

The authors provide validation and technique of circadian phototherapy of bronchial asthma. Therapeutic effect of the method occurs because of correction of internal asynchronism, stimulation of endogenic synthesis of corticosteroids, antidepressive action.

[Phototherapy and sleep deprivation as additional methods of treating bronchial asthma patients].

Correction of internal desynchronosis in bronchial asthma by means of phototherapy and partial sleep deprivation was instituted in 4 hormone-dependent patients with bronchial asthma for 13 months. The results were positive: the frequency and severity of night attacks reduced, the condition of the patients improved.

[Experience with the Chinese therapeutic gymnastics in the complex treatment of patients with bronchial asthma].

A group of 8 bronchial asthma patients underwent daily conditioning involving Chinese specific exercises and the respiratory complex. The patients achieved a positive response. This justifies the addition of the above conditioning systems to combined ambulatory treatment of bronchial asthma.

[The outpatient corticosteroid therapy of bronchial asthma patients].

The author reports his three-year experience of treatment of 17 hormone-dependent patients with bronchial asthma. It was established that intake of the entire 24-hour dose of corticosteroids agents during the night and morning hours in minimal maintenance doses with correction of the dosage depending on the patient's feelings an effective variant of long-term hormone therapy of bronchial asthma.

[Use of the initial portion of the melting curve for determining locally denatured sites in DNA radiation damage].

A simple approach is proposed to determine locally denatured sites and stability characteristics of secondary DNA structure. The method is based on the analysis of the initial part of melting curve and the determination of changes in the optical density of DNA after heating up to a fixed temperature. The potentiality of the approach is illustrated by the experiments with DNA containing defects in the secondary structure caused by gamma-irradiation in vitro.

[Effect of solvent structure on amide reaction with native DNA molecules. II. Aqueous acetamide mixtures].

The influence of acetamide (AA) on the native DNA molecule conformation has been studied by methods of flow birefringence and viscometry. On one hand, it was shown that hydrodynamical and optical behaviour of the macromolecule at extremely low additions of AA is qualitatively the same as in the presence of nonelectrolytes which stabilize the water structure. On the other hand, the influence of intermediate and large AA concentrations on the native DNA molecule conformation is qualitatively the same as of corresponding urea concentrations, which is known to be a structure-breaker.

[Effect of salts, stabilizing and destabilizing the structure of water, on the stacking association of adenosine].

A spectrophotometric study, based on the concentration relationship of electron absorption spectra, of the effects of salts which stabilize and destabilize the water structure on the constant (K) of adenosine: stacking association has been carried out. A significant decrease of K was observed in NaClO4 which embodied strong destabilizing effect. Opposite effect was observed on other salts studied.

[Temperature dependence of the electronic absorption spectra of polynucleotides and their components].

The temperature dependence of UV-absorption spectra of solutions nucleic bases, nucleosides, nucleotides and metilated bases, uncapable of tautomerization has been studied. The nature of such dependence, its connection with hypochromic effect is discussed. It is shown that for some methods of investigating polynucleotides it is necessary to take into account the temperature changes spectra of monomers.