Publications by authors named "Maeve B Greenberg"
Article Synopsis
- This study explores how neuronal cell transplantation affects neurogenesis (the formation of new neurons) after a stroke in rats, specifically following middle cerebral artery occlusion (MCAO).
- It builds on previous findings that transplanting neuronal precursors from human embryonic stem cells can reduce brain damage and improve recovery.
- Results showed that transplantation increased neurogenesis in a specific brain area (ipsilateral subventricular zone) but not in other regions, indicating that such therapies might influence the brain's natural ability to generate new neurons post-stroke.
Neural precursor cell (NPC) transplantation may have a role in restoring brain function after stroke, but how aging might affect the brain's receptivity to such transplants is unknown. We reported previously that transplantation of human embryonic stem cell (hESC)-derived NPCs together with biomaterial (Matrigel) scaffolding into the brains of young adult Sprague-Dawley rats 3 weeks after distal middle cerebral artery occlusion (MCAO) reduced infarct volume and improved neurobehavioral performance. In this study, we compared the effect of NPC and Matrigel transplants in young adult (3-month-old) and aged (24-month-old) Fisher 344 rats from the National Institute on Aging's aged rodent colony.
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