Major adverse cardiovascular events are associated with necroptosis during severe COVID-19.

Background: The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed to determine if SARS-CoV-2 can induce necrotic cell death to promote MACE in patients with severe COVID-19.

Methods: This observational prospective cohort study includes experiments with hamsters and human samples from patients with severe COVID-19.

Necroptosis Drives Major Adverse Cardiovascular Events During Severe COVID-19.

Background The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed to determine if SARS-CoV-2 can infect the heart to kill cardiomyocytes and induce MACE in patients with severe COVID-19. Methods This observational prospective cohort study includes experiments with hamsters and human samples from patients with severe COVID-19.