Publications by authors named "Maeva Ruel"
Article Synopsis
- Bone metastasis occurs in over 70% of advanced breast cancer patients, but the mechanisms behind it are not well understood.
- Research indicates that the ZNF217 oncogene plays a significant role in bone metastasis, with higher levels of its expression correlating to increased risk in patients.
- In experiments, ZNF217 was shown to alter gene expression related to bone metastasis and activate the BMP pathway, suggesting that targeting ZNF217 or the BMP signaling could be a potential strategy for preventing bone metastases in breast cancer.
Degenerative disc disease (DDD) primarily affects the central part of the intervertebral disc namely the nucleus pulposus (NP). DDD explains about 40% of low back pain and is characterized by massive cellular alterations that ultimately result in the disappearance of resident NP cells. Thus, repopulating the NP with regenerative cells is a promising therapeutic approach and remains a great challenge.
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- Metastatic pheochromocytomas and paragangliomas (PPGL) are aggressive tumors linked to mutations in the SDHB gene, showing a hypermethylation pattern and signs of epithelial-to-mesenchymal transition (EMT).
- Researchers created a mouse model with Sdhb knockout in chromaffin cells that exhibited increased movement, invasion, and adhesion, characteristic of a metastatic phenotype.
- The study identified key genes involved in this aggressive behavior, particularly Krt19, which was epigenetically silenced in Sdhb-deficient cells but could be reactivated, impacting cell migration and adhesion, highlighting the relationship between hypermethylation, EMT, and metastasis following SDHB dysfunction.