The effect of TGF-β polymorphisms on pulmonary disease progression in patients with cystic fibrosis.

Background: Transforming Growth Factor-β (TGF-β) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function.

Aim: The aim of this study was to assess the relationship between genetic TGF-β polymorphisms and pulmonary disease progression in CF patients.