Seeing or believing in hyperplexed spatial proteomics via antibodies: New and old biases for an image-based technology.

Hyperplexed in-situ targeted proteomics via antibody immunodetection (i.e., >15 markers) is changing how we classify cells and tissues.

Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity.

Per- and polyfluoroalkyl substances (PFAS) are abundantly used in a plethora of products with applications in daily life. As a result, PFAS are widely distributed in the environment, thus providing a source of exposure to humans. The majority of human exposure to PFAS is attributed to the human diet, which encompasses drinking water.

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures.

Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults.

Beautification of images by generative adversarial networks.

Finding the properties underlying beauty has always been a prominent yet difficult problem. However, new technological developments have often aided scientific progress by expanding the scientists' toolkit. Currently in the spotlight of cognitive neuroscience and vision science are deep neural networks.

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach.

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected by key event relationships, leading to the actual adverse outcome. AOP networks are to be considered living documents that should be frequently updated by feeding in new data.

Pannexin1 channels in the liver: an open enemy.

Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels.

Data sharing upon request and statistical consistency errors in psychology: A replication of Wicherts, Bakker and Molenaar (2011).

Sharing research data allows the scientific community to verify and build upon published work. However, data sharing is not common practice yet. The reasons for not sharing data are myriad: Some are practical, others are more fear-related.

Correction notices in psychology: impactful or inconsequential?

Science is self-correcting, or so the adage goes, but to what extent is that indeed the case? Answering this question requires careful consideration of the various approaches to achieve the collective goal of self-correction. One of the most straightforward mechanisms is individual self-correction: researchers rectifying their mistakes by publishing a correction notice. Although it offers an efficient route to correcting the scientific record, it has received little to no attention from a metascientific point of view.

Sound-Symbolism Effects in the Absence of Awareness: A Replication Study.

People have been shown to link particular sounds with particular shapes. For instance, the round-sounding nonword tends to be associated with curved shapes, whereas the sharp-sounding nonword is deemed to be related to angular shapes. People's tendency to associate sounds and shapes has been observed across different languages.

Characterizing the transformation near indents and cracks in clinically used dental yttria-stabilized zirconium oxide constructs.

Objectives: Tetragonal zirconia polycrystal (TZP) materials are widely used for full ceramic partial dentures, even though their mechanical properties might change during service. A key property for the durability of the constructs is thought to be an inhibition of crack propagation by phase transformation toughening. Because dental prosthesis are ground and polished for adjustment purposes, it is important to understand the effects of mechanical surface treatments, on localized transformation and around the propagating cracks.

Tetragonal and cubic zirconia multilayered ceramic constructs created by EPD.

The interest in electrophoretic deposition (EPD) for nanomaterials and ceramics production has widely increased due to the versatility of this technique to effectively combine different materials in unique shapes and structures. We successfully established an EPD layering process with submicrometer sized powders of Y-TZP with different mol percentages of yttrium oxide (3 and 8%) and produced multilayers of alternating tetragonal and cubic phases with a clearly defined interface. The rationale behind the design of these multilayer constructs was to optimize the properties of the final ceramic by combining the high mechanical toughness of the tetragonal phase of zirconia together with the high ionic conductivity of its cubic phase.

Monoclinic phase transformations of zirconia-based dental prostheses, induced by clinically practised surface manipulations.

Full-ceramic zirconia crowns and bridges have become very popular with dentists and patients because of their excellent esthetics and mechanical properties. We studied phase transformations within the outermost surface layer of 3 mol.% yttria-stabilized zirconia (Y-TZP) samples of small, clinically relevant thicknesses, manipulated by polishing, grinding and fracture as might be encountered in everyday clinical practice.

Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities.

The transport of essential metals and other nutrients across tight membrane barriers such as the gastrointestinal tract and blood-brain barrier is mediated by specific transport mechanisms. Specific transporters take up metals at the apical surface and export them at the basolateral surface, and are involved in their intracellular distribution. Transporters for each of the major essential metals, calcium, iron and zinc, have been identified.