Publications by authors named "Maelle Lebras"

Article Synopsis
  • - The study investigates the long-term effectiveness of different surgical methods for patients with insulinomas related to Multiple Endocrine Neoplasia type 1 (MEN1), analyzing data from surgeries performed between 1957 and 2010.
  • - Out of 73 patients analyzed, distal pancreatectomy (DP) was found to have the lowest risk of recurrent hypoglycemia compared to total pancreatectomy/cephalic duodenopancreatectomy (TP/CDP) and enucleation (E).
  • - Although E showed no long-term complications, DP was prioritized due to its lower recurrence rate of hypoglycemia, suggesting it as the best surgical option for these patients.
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Context: HIF2A germline mutations were known to cause congenital polycythemia. Recently, HIF2A somatic mutations were found in several patients with polycythemia and paraganglioma, pheochromocytoma, or somatostatinoma, suggesting the occurrence of a de novo postzygotic HIF2A mutation that has not been demonstrated clearly.

Patients: Patient 1 is a woman suffering from polycythemia diagnosed at the age of 16 years.

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