Publications by authors named "Mael Rollin"
The variable domains (V-DOMAIN) of the antigen receptors, immunoglobulins (IG) or antibodies and T cell receptors (TR), which specifically recognize the antigens show a huge diversity in their sequences. This diversity results from the complex mechanisms involved in the synthesis of these domains at the DNA level (rearrangements of the variable (V), diversity (D), and joining (J) genes; N-diversity; and, for the IG, somatic hypermutations). The recognition of V, D, and J as "genes" and their entry in databases mark the creation of IMGT by Marie-Paule Lefranc, and the origin of immunoinformatics in 1989.
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- * The system provides scientific resources like databases, tools, and reference directories based on IMGT-ONTOLOGY to help researchers understand immune responses.
- * Research is organized into three main areas: identifying immunoglobulin and T cell receptor genes (Axis I), analyzing immune repertoires in various conditions (Axis II), and studying structural changes and engineering of antibodies and T cell receptors (Axis III).