Publications by authors named "Mael Gennequin"
Background: Ventilator acquired pneumonia (VAP) is a frequent and serious complication in ICU. Second episodes of VAP are common in trauma patients and may be related to severity of underlying conditions, treatment or bacterial factors of the first VAP. The aim of this study was to identify risk factors of second VAP episodes in trauma injured patients (defined as the development of a new pulmonary infection during or remotely following the first episode).
View Article and Find Full Text PDFBackground: Complications after removal of totally implanted vascular access devices. (TIVADs) have not been studied widely. The aim of this study was to assess the prevalence and risk factors of these complications.
View Article and Find Full Text PDFEmpiric antimicrobial therapy for early-onset pneumonia in severe trauma patients.
Eur J Trauma Emerg Surg
August 2022
Article Synopsis
- The study focuses on the bacterial ecology in pneumonia cases among severe trauma patients, suggesting that narrow-spectrum antibiotics could be effective due to the mostly commensal nature of the bacteria involved.
- A cohort of 370 patients was analyzed, identifying key risk factors for treatment failure with narrow-spectrum antibiotics, namely prior antimicrobial therapy for 48 hours or more, and being over 30 years old.
- A prediction score was developed to help clinicians assess the risk of antibiotic resistance in patients, providing high sensitivity for identifying those at risk while aiming to optimize antibiotic use and reduce reliance on broad-spectrum treatments.
Article Synopsis
- The study aimed to identify the incidence and risk factors for relapse of methicillin sensitive Staphylococcus aureus (MSSA) ventilator-associated pneumonia (VAP) in patients with trauma and non-traumatic brain injuries.
- A total of 165 ICU patients developed MSSA-VAP, with 33% experiencing a relapse, which included treatment failure and other pathogen VAP.
- Key predictors of relapse include the presence of Streptococcus species and oropharyngeal flora, Glasgow coma scale scores, need for emergency surgery, and acute respiratory distress syndrome.