Fabrication of an ultra-sensitive electrochemical DNA biosensor based on CT-DNA/NiFeONPs/Au/CPE for detecting rizatriptan benzoate.

A novel and first electrochemical biosensor based on Deoxyribonucleic acid (DNA) as a biological component to measure an antimigraine drug, rizatriptan benzoate (RZB) for patients under treatment in biological samples was developed. A carbon paste electrode (CPE) was modified by calf thymus (CT) double-stranded (ds)-DNA, nickel ferrite magnetic nanoparticles (NiFeONPs), and gold nanoparticles (AuNPs). The morphology of the CT-DNA/NiFeONPs/AuNPs/CPE was characterized by Field emission scanning electron microscope (FESEM).

Simultaneous voltammetric determination of rizatriptan and acetaminophen using a carbon paste electrode modified with NiFeO nanoparticles.

Nickel-ferrite nanoparticles (NiFeO) were synthesized by a hydrothermal method. They were used to modify a carbon paste electrode (CPE) and to prepare an electrochemical sensor for simultaneous determination of rizatriptan benzoate (RZB) and acetaminophen (AC). The structure and morphology of the bare CPE and modified CPE were studied using field emission scanning electron microscopy, while the structural characterization of NiFeO was performed via X-ray diffraction.