Protein modification in neurodegenerative diseases.

Posttranslational modifications play a crucial role in governing cellular functions and protein behavior. Researchers have implicated dysregulated posttranslational modifications in protein misfolding, which results in cytotoxicity, particularly in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. These aberrant posttranslational modifications cause proteins to gather in certain parts of the brain that are linked to the development of the diseases.

P-tau Accumulation Triggers Neurodegeneration after Ischemic Stroke.

Ischemic stroke is a neurological deficit caused by a lack of blood supply to the brain. Evidence indicates that ischemic stroke leads to dementia of the Alzheimer's disease (AD) phenotype; however, the underlying molecular mechanism remains unclear. Tau hyperphosphorylation is a common pathological feature of both ischemic stroke and AD.