Publications by authors named "Mads Peder Rolfsen"
Introduction: Bacterial infection and Modic changes (MCs) as causes of low back pain (LBP) are debated. Results diverged between two randomised controlled trials examining the effect of amoxicillin with and without clavulanic acid versus placebo on patients with chronic LBP (cLBP) and MCs. Previous biopsy studies have been criticised with regard to methods, few patients and controls, and insufficient measures to minimise perioperative contamination.
View Article and Find Full Text PDFStudy Design: Secondary analyses of a randomized trial [Antibiotics In Modic changes (MCs) study].
Objective: To assess whether or not reduced MC edema over time is related to reduced disability and pain in patients with chronic low back pain (LBP).
Summary Of Background Data: It is not clear whether or not reduced MC edema implies improved clinical outcomes.
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study).
BMC Musculoskelet Disord
July 2020
Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin treatment in patients with chronic low back pain and type I or II Modic changes at the level of a previous lumbar disc herniation.
View Article and Find Full Text PDFArticle Synopsis
- Limited reliability data on spinal edema changes using MRI STIR sequences exist, prompting assessment of inter-observer reliability for Modic changes on lumbar spine images.
- In a study with 120 patients, three radiologists independently evaluated Modic changes and related STIR signal increases, measuring agreement through kappa values.
- Results showed very good agreement for detecting STIR signal increases, but moderate reliability for accurately categorizing their size and extent.
Objective: To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes).
Design: Double blind, parallel group, placebo controlled, multicentre trial.
Setting: Hospital outpatient clinics at six hospitals in Norway.