Publications by authors named "Mads Nyhuus Bendix Rasch"
Article Synopsis
- Anifrolumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE) but comes with a heightened risk of viral infections, notably herpes zoster (HZ), with reported rates of 6.1% in clinical trials.
- In two unique cases, SLE patients on anifrolumab experienced severe herpesvirus infections—disseminated HSV-2 and HZ encephalitis—marking a concerning new trend not previously documented.
- The findings underline the importance of assessing patients' viral infection history and recommending vaccinations, like the recombinant zoster vaccine, before starting anifrolumab therapy to mitigate infection risks.
Article Synopsis
- Highlights the importance of recognizing VEXAS syndrome in patients with unexplained inflammation, anemia, and related symptoms.
- VEXAS usually affects older males (over 60) and is characterized by inflammation and macrocytic anemia.
- The review discusses the pathogenesis, symptoms, diagnosis, and treatment options for VEXAS, aiming to improve awareness among clinicians.
Patients with VEXAS diagnosed in a Danish tertiary rheumatology setting have highly elevated inflammatory markers, macrocytic anaemia and negative autoimmune biomarkers.
RMD Open
September 2022
Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is an autoinflammatory condition with overlapping features of rheumatology and haematology caused by somatic mutations in the UBA1 gene. Patients present with highly variable symptoms and their path towards diagnosis are often complicated and characterised by extensive examinations. It is, therefore, pivotal that clinicians become familiar with the clinical presentation of VEXAS to advance identification of patients with the disease.
View Article and Find Full Text PDFObjectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range.
Methods: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort.