Publications by authors named "Mads M Nygaard"
Article Synopsis
- Peptides that target specific protein interactions present a promising therapy option, bridging the gap between small molecules and therapeutic proteins, but they face challenges like poor stability and low permeability.
- Cyclization of peptides, including techniques like "stapling," helps to create more stable and permeable cyclic peptides by enhancing their structure and resistance to metabolism.
- Through a detailed analysis of various cyclization methods, the study identifies effective cyclic peptides that target Mint2, with all-hydrocarbon stapling significantly boosting their stability and cell permeability.
Proc Natl Acad Sci U S A
April 2019
Article Synopsis
- FFAR1/GPR40 is a receptor that binds to special fatty acids in specific locations between its parts.
- When the fatty acid is removed, important parts of the receptor change shape, causing a nearby pocket to close.
- Scientists found a new compound that can keep this pocket open, which could help in creating better medicines for diabetes by targeting this receptor in a new way.
