Synopsis of recent research by authors named "Mads D Larsen"
- Mads D Larsen's research focuses on the glycosylation patterns of IgG antibodies, particularly how variations in fucosylation influence immune responses, inflammation, and protective functions against infections such as COVID-19 and malaria.
- Recent studies highlighted the dynamic regulation of IgG glycosylation at the clonal level and the impact of vaccination on the induction of afucosylated IgG1, which demonstrates varying effects in naive versus antigen-experienced individuals.
- His findings reveal that afucosylated IgG can enhance antibody effector functions and inform disease severity correlations in COVID-19, suggesting both protective roles and potential exacerbatory effects in the context of inflammation and immune responses.