Publications by authors named "Madoka Sakuramachi"
Background: To analyze in a prospective study the long-term safety and efficacy of 3-dimensional conformal radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) for Japanese women with early breast cancer.
Methods: Breast cancer patients with pathological tumor size ≤ 3 cm, age ≥ 20 years, lumpectomy with at least a 5 mm margin, and ≤ 3 positive axillary nodes were eligible. APBI was delivered by 3D-CRT at a dose of 38.
Article Synopsis
- * A study evaluated a new method for visualizing 3D dose distributions using panoramic reconstruction computed tomography images in four head and neck cancer patients, achieving a high correlation in dose metrics.
- * The method aids dentists by providing clear visualizations of radiation doses that can lead to complications, improving the management of dental care for these patients.
Background: To protect the rectum and bladder from high dose exposure, the Japanese guidelines for managing uterine cervical carcinoma recommend pelvic irradiation with central shielding (CS). Conversely, the European Society for Radiotherapy and Oncology (ESTRO) and the American Brachytherapy Society (ABS) guidelines recommend delivering ≥85 Gy to high-risk clinical target volume D (CTV D). In this study, we investigated whether a gel spacer can enable the safe delivery of the ESTRO/ABS-recommended doses to the target while observing dose constraints for the OARs without using CS in external beam radiation therapy (EBRT).
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- * A 73-year-old woman with cervical cancer received targeted radiation treatment, where traditional methods fell short due to the proximity of her sigmoid colon, necessitating the injection of hydrogel into the meso-sigmoid.
- * Results showed that using the hydrogel spacer successfully decreased the radiation dose to the sigmoid colon while still effectively targeting the high-risk areas of cancer, suggesting it as a viable technique for similar cases.
Article Synopsis
- This study presents the first case of using a linear accelerator-based boron neutron capture therapy (BNCT) system to treat a patient with cutaneous malignant melanoma in a clinical trial that started in November 2019.
- A patient with a localized melanoma who opted out of surgery and chemotherapy received BNCT after being administered boronophenylalanine (BPA), leading to a gradual improvement in their condition over 12 months.
- While the patient experienced some mild side effects, there were no serious adverse events, indicating that accelerator-based BNCT could be a promising new treatment option for this type of cancer.
Article Synopsis
- Brachytherapy is a targeted radiation therapy directly applied to tumors, offering better local control compared to external beam radiation therapy (EBRT), but is usually more invasive.
- Patients receiving brachytherapy for head and neck cancers face significant challenges, including physical issues, nutritional needs, and pain management.
- The article aims to educate radiation oncologists and nurses on nursing care for patients undergoing high-dose rate interstitial brachytherapy (ISBT) due to the lack of existing resources on this topic.
Currently, tongue cancers are primarily managed by surgery, and interstitial brachytherapy is only recommended for a selected group of early state T1-2N0 patients who refuse surgery or are medically inoperable. In this report, a case with T3N2cM0 tongue cancer who has been effectively treated by the combination of concurrent chemoradiotherapy involving volumetric arc therapy and boost high-dose rate interstitial brachytherapy is presented. Of course, surgery remains the main treatment strategy for tongue cancer patients; however, the authors believe that if volumetric arc therapy is carefully planned to reduce the mandible dose as much as possible and high-dose rate interstitial brachytherapy with a mouthpiece that protects the mandible is combined, it is possible to treat T3N2 disease, and this can be considered for patients who want to preserve organ function.
View Article and Find Full Text PDFPurpose: Pelvic sidewall recurrence after hysterectomy for uterine malignances has a poor prognosis, and the salvage therapy for this type of recurrence is still challenging. The purpose of this study was to investigate the efficacy of freehand high-dose-rate interstitial brachytherapy (HDR-ISBT) through the perineum using transrectal ultrasonography for this disease.
Methods And Materials: We retrospectively evaluated 42 patients with pelvic sidewall recurrence after hysterectomy for uterine cervical and endometrial cancers.
Background: Stereotactic radiosurgery (SRS) has been accepted as a therapeutic option for intracranial meningiomas; however, the detailed data on outcomes in elderly patients remain unclear.
Objective: To delineate the efficacy of SRS for meningiomas in elderly patients.
Methods: The outcomes of 67 patients aged ≥65 yr who underwent SRS for benign intracranial meningioma (World Health Organization grade I) between 1990 and 2014 at our institution were retrospectively analyzed.
Article Synopsis
- The study aimed to assess how effective MRI is in identifying remaining tumors after Gamma Knife radiosurgery for brain metastases, using data from autopsy cases.
- Researchers tested two hypotheses: whether a single MRI could detect tumors and if multiple MRIs would improve detection accuracy.
- Results indicated that a single MRI couldn't clearly differentiate between treatment success and failure, while a series of MRIs provided better insights into treatment responses over time.
Objective: Cerebellar arteriovenous malformation (C-AVM) is poorly tolerated because of its aggressive natural history. The aim of this study was to delineate long-term outcomes of Gamma Knife stereotactic radiosurgery (GKRS) for C-AVM.
Methods: The outcomes of 45 patients who underwent GKRS for C-AVMs at our institution were retrospectively analyzed.