Publications by authors named "Madlen Rossnagel"
Article Synopsis
- Lactic acid bacteria (LAB) are important in both biotechnology and human health, but some, like Enterococcus faecalis, have developed multidrug resistance, complicating infection control.
- The study focused on how a glutamine auxotrophy mutation in E. faecalis affects its metabolism and protein adaptations to pH changes, essential for understanding its behavior in the human body and food industry.
- Results revealed that the mutant strain had higher energy demands due to inefficient glutamine regulation, emphasizing the importance of amino acid transport specificity in metabolic modeling.
Article Synopsis
- Severe infectious diseases trigger an intense and often unbalanced immune response, and human antithrombin (hAT) plays a key role in regulating inflammation.
- Researchers identified three proteins (CD13, CD300f, and LRP-1) that bind to hAT on human monocytes and help inhibit a major inflammatory pathway (NF-κB), specifically focusing on the less common β-isoform (hβAT) of hAT.
- Studies showed that individuals with a mutation in hβAT exhibited reduced inflammation, and in mice models, treatment with hβAT after E. coli infection improved survival rates and decreased inflammation severity.
Background: In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of lipid droplets in plants, are described as allergens in sesame, peanut and hazelnut.
View Article and Find Full Text PDF