Antioxidant Coated Microelectrode Arrays: Effects on Putative Inhibitory and Excitatory Neurons.

Intracortical microelectrode arrays (MEAs) are used to record neural activity in vivo at single-cell resolution for both neuroscience studies and for engineering restorative devices such as brain-computer interfaces (BCIs). The recording performance of these devices are known to degrade over weeks to months after implantation due, in part, to neuroinflammation and oxidative stress. Characterizing and mitigating the degradation of recording performance is of particular interest for chronic applications.

Reactive Amine Functionalized Microelectrode Arrays Provide Short-Term Benefit but Long-Term Detriment to Recording Performance.

Intracortical microelectrode arrays (MEAs) are used for recording neural signals. However, indwelling devices result in chronic neuroinflammation, which leads to decreased recording performance through degradation of the device and surrounding tissue. Coating the MEAs with bioactive molecules is being explored to mitigate neuroinflammation.