Publications by authors named "Madison Rackear"
Article Synopsis
- Monoclonal antibody therapies for cancer have seen significant success but are primarily focused on specific cell surface antigens, leaving many potential targets inside cells untapped.
- Recent research has focused on humanizing a lupus-derived autoantibody, 3E10, which can penetrate cells and target tumors effectively.
- The study found that the efficiency of this cell uptake relies on a specific transporter and that a particular human variant of 3E10 retains the ability to bind to RAD51, potentially enhancing cancer treatment by inhibiting DNA repair mechanisms.
