Publications by authors named "Madison L Boisvert"
Article Synopsis
- - The study focuses on zwitterions phosphorylcholine (PC) and phosphoethanolamine (PE), which are commonly attached to sugars in biological structures like polysaccharides and glycoconjugates, playing a role in how certain parasites evade host immunity by modifying N-glycans and glycosphingolipids.
- - Researchers used functional metagenomic screening to find a novel bacterial enzyme, GlcNAc-PDase, that specifically removes PC from the sugar N-acetylglucosamine (GlcNAc-6-PC), showing strong substrate preference and limited activity on other modified sugars.
- - GlcNAc-PDase is classified in a new subfamily of the
Background: Sulfate modification of N-glycans is important for several biological functions such as clearance of pituitary hormones or immunoregulation. Yet, the prevalence of this N-glycan modification and its functions remain largely unexplored. Characterization of N-glycans bearing sulfate modifications is hampered in part by a lack of enzymes that enable site-specific detection of N-glycan sulfation.
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