Publications by authors named "Madi Wenger"
Age-associated declines in aerobic capacity promote the development of various metabolic diseases. In rats selectively bred for high/low intrinsic aerobic capacity, greater aerobic capacity reduces susceptibility to metabolic disease while increasing longevity. However, little remains known how intrinsic aerobic capacity protects against metabolic disease, particularly with aging.
View Article and Find Full Text PDFDivergence in aerobic capacity influences hepatic and systemic metabolic adaptations to bile acid sequestrant and short-term high-fat/sucrose feeding in rats.
Am J Physiol Regul Integr Comp Physiol
December 2023
Article Synopsis
- High and low aerobic capacity in rats affects their metabolism and risk for metabolic diseases, particularly in response to high-fat diets (HFDs).
- The study tested the effects of a bile acid sequestrant (BA-Seq) on male rats selectively bred for high (HCR) or low (LCR) aerobic capacities while on a 1-week HFD.
- Results showed that BA-Seq improved lipid and bile acid excretion in both groups; however, HCR rats exhibited better adaptability in their metabolism, leading to greater energy loss compared to LCR rats.