Quantification and assessment of hazardous mercury emission from industrial process and other unattended sectors in India: A step towards mitigation.

Hazardous pollutants like Mercury (Hg) have emerged as a pressing challenge in recent times where the expanding industrial sector is regarded as the major source in developing country India. In this study, we are trying to identify all possible industrial sectors at district level to quantify Hg emission load across India for the year 2019 using IPCC methodology where the country-specific technological emission factors are used. We have included 5 major sectors out of which emission from coal combustion in thermal power plants accounts for 186.

A hybridized red deer and rough set clinical information retrieval system for hepatitis B diagnosis.

Healthcare is a big concern in the current booming population. Many approaches for improving health are imposed, such as early disease identification, treatment, and prevention. Therefore, knowledge acquisition is highly essential at different stages of decision-making.

Molecular characterization of typing and subtyping of Staphylococcal cassette chromosome SCC types I to V in methicillin-resistant from clinical isolates from COVID-19 patients.

Background And Objectives: Methicillin resistance is acquired by the bacterium due to gene which codes for penicillin-binding protein (PBP2a) having low affinity for β-lactam antibiotics. gene is located on a mobile genetic element called staphylococcal cassette chromosome (SCC). SCC genomic island comprises two site-specific recombinase genes namely and [cassette chromosome recombinase] accountable for mobility.

Assessment of hazardous radionuclide emission due to fly ash from fossil fuel combustion in industrial activities in India and its impact on public.

Traditionally coal has been extensively used as a dominating fossil fuel in a wide range of industries due to its abundance. In India, industries like thermal power plants, cement industries, iron, and steel industries along with many captive power plants consume a huge quantity of coal each year to meet energy demand. Coal combustion releases blackish-grey colored fly ash waste is one of the most imperative sources of radionuclides like Radium (Ra), Thorium (Th), Potassium (K) and Uranium (U).

Differential interaction of cerium chloride with bovine liver catalase: A computational and biophysical study.

In this study, Cerium chloride-induced conformational changes of Bovine Liver Catalase (BLC) has been investigated by molecular docking and further supported by various biophysical techniques. The temporal change of catalytic activity of BLC has also been studied in presence of Ce(III) with different buffer solution in vitro at 25 °C. The differential binding of Ce(III) to BLC observed by simulation study was well supported by the differential regulation of BLC activity in different buffers.

Antibacterial Loaded Spray Dried Chitosan Polyelectrolyte Complexes as Dry Powder Aerosol for the Treatment of Lung Infections.

Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections. Chitosan polyelectrolyte complex microparticles were formulated by spray drying process.

Microbial community in packed bed bioreactor involved in nitrate remediation from low level radioactive waste.

Nitrate is the second largest contaminant of agriculture soil after pesticides. It also is a major pollutant from nuclear and metallurgical operations. Conventional methods for nitrate removal suffers from high cost and complexity leaving bioremediation as a viable alternative strategy.

Formulation optimization and characterization of spray dried microparticles for inhalation delivery of doxycycline hyclate.

The local delivery of antibiotics in the treatment of infectious respiratory diseases is an attractive alternative to deliver high concentration of antimicrobials directly to the lungs and minimize systemic side effects. In this study, inhalable microparticles containing doxycycline hyclate, sodium carboxymethylcellulose, leucine and lactose were prepared by spray drying of aqueous ethanol formulations. Box-Behnken design was used to study the influence of various independent variables such as polymer concentration, leucine concentration, ethanol concentration and inlet temperature of the spray dryer on microparticle characteristics.

Design and evaluation of microporous membrane coated matrix tablets for a highly water soluble drug.

Microporous coated matrix tablet consists of a microporous membrane which is produced directly from a nonporous polymer coating during transit in the gastro-intestinal tract. In the present study, efforts have been made to develop and evaluate the in-vitro performance of a matrix embedded microporous controlled release system to deliver a drug with high aqueous solubility (> or =3 g/ml), high pK(a) (> or =9.0) and low molecular weight (<500 Da).

Polymer based solutions of bupranolol hydrochloride for intranasal systemic delivery.

The present study was aimed at developing intranasal polymer based solutions as alternative route for systemic delivery of Bupranolol hydrochloride (BPH). It is a potent β-blocker drug which upon oral administration undergoes extremely high hepatic first-pass metabolism (>90% in humans). The polymeric solutions were prepared using varying concentrations of polymers like sodium alginate, chitosan, sodium carboxymethylcellulose, methylcellulose (MC), polyvinyl alcohol, carbopol, hydroxypropyl MC, and hydroxypropyl cellulose.

Design and evaluation of bioadhesive in-situ nasal gel of ketorolac tromethamine.

The present study was aimed at developing safe and effective bioadhesive gelling systems of ketorolac tromethamine, a potent non-narcotic analgesic with moderate anti-inflammatory activity for nasal systemic delivery. Chitosan and pectin based gelling systems were prepared with variables like polymer concentration and type. These systems were characterized in terms of their physical properties, in vitro bioadhesion, in vitro drug release and long-term stability.