Publications by authors named "Madhushika Ratnayake"
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Synopsis of recent research by authors named "Madhushika Ratnayake"
Madhushika Ratnayake's research primarily focuses on the genetic factors influencing skeletal disorders, particularly developmental dysplasia of the hip (DDH) and osteoarthritis (OA), utilizing genome-wide association studies (GWAS) to identify susceptibility loci.
Her studies revealed significant genetic associations, such as the involvement of the GDF5 gene in osteoarthritis susceptibility and identified specific SNPs linked to increased risk of hip OA, highlighting the genetic complexity of these conditions.
Ratnayake employs a combination of bioinformatics and experimental methods, demonstrating the effects of genetic variants on chondrocyte function and cartilage health, which could inform future therapeutic strategies for managing skeletal diseases.
