A Virtual Drug Discovery Screening Illuminates Campesterol as a Potent Estrogen Receptor Alpha Inhibitor in Breast Cancer.

Breast cancer remains a global health challenge, and innovative strategies are required to target estrogen receptor α (ERα), a key player in its development. This study investigates the potential of campesterol, a natural phytosterol, as an ERα inhibitor for breast cancer. Our approach integrates , , and experiments to assess the therapeutic potential of campesterol.

Two-Photon-Responsive "TICT + AIE" Active Naphthyridine-BF Photoremovable Protecting Group: Application for Specific Staining and Killing of Cancer Cells.

The combined effects of twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) phenomena have demonstrated a significant influence on excited-state chemistry. These combined TICT and AIE features have been extensively utilized to enhance photodynamic and photothermal therapy. Herein, we demonstrated the synergistic capabilities of TICT and AIE phenomena in the design of the photoremovable protecting group (PRPG), namely, NMe-Napy-BF.

Nanoparticle-mediated gene therapy as a novel strategy for the treatment of retinoblastoma.

Over the last two decades, nanoparticulate delivery systems have revolutionized cancer treatment by achieving target-specific delivery, enhanced bioavailability, and improved toxicity profile. The increasing interest in nanotechnology for cancer treatment stems from the unique physicochemical properties of nanoparticles (for instance, small size, surface characteristics, etc.).