Publications by authors named "Madhuri P"

Article Synopsis
  • Leishmaniasis, Chagas disease, and sleeping sickness are diseases caused by protozoan parasites, and the inflammatory protein platelet activating factor acetyl hydrolase (PAF-AH) is identified as a key player in their development, making it a drug target.
  • Researchers aligned PAF-AH sequences from various organisms, built models based on the human enzyme's structure, and conducted virtual drug screenings using the ZINC library to find potential treatments.
  • Results showed that PAF-AH enzymes from the parasites and humans are similar but have important differences, allowing the identification of three promising drug candidates that could selectively target the parasitic enzymes while minimizing effects on human PAF-AH.
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Here we report a case of peri-ovarian hematoma following ovum pick-up in a patient in a pooling cycle IVF (in vitro fertilization). We have attempted to discuss the possible mechanisms for the development of hematoma in such patients, the common clinical presentation, monitoring, and management of these cases. The decision to operate or to manage conservatively forms an important aspect of managing such patients.

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Amitraz is a worldwide available pesticide of formamidine chemical family, proven to have reversible toxic effects on both animals and humans. Upon intoxication by ingestion, inhalation, or dermal route, it can cause various central nervous system (CNS), CVS, respiratory and gastrointestinal effects, some of which may be life threatening. Because of lack of specific antidote patients are usually managed with supportive and symptomatic management.

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Switchable liquid crystal (LC) composites are a unique and attractive class of functional materials due to their extensive use in various applications including smart and privacy windows. Demand for developing smart windows with good switchable performance has steadily increasing in the past decades due to their importance in energy saving. Herein, we present the use of novel and highly active switchable LC composite material-octadecanol-doped LC-prepared via a facile, low-cost, and scalable process, for thermally or electrically controlled transparency windows.

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In this paper a novel ligand debip (2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f] [1, 10]phenanthroline) and its Ru(II) polypyridyl complexes [Ru(L)(debip)], (L = phen (1), bpy (2) and dmb (3)) have been synthesized and characterized by spectroscopic techniques. The DNA binding studies for all these complexes were examined by absorption, emission, quenching studies, viscosity measurements and cyclic voltammetry. The light switching properties of complexes 1-3 have been evaluated.

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We report the design, synthesis, detailed characterization, and analysis of a new multifunctional π-conjugated bola-amphiphilic chromophore: oligo-(p-phenyleneethynylene)dicarboxylic acid with dialkoxyoctadecyl side chains (OPE-C-1). OPE-C-1 shows two polymorphs at 123 K (OPE-C-1') and 373 K (OPE-C-1″), whose crystal structures were characterized via single crystal X-ray diffraction. OPE-C-1 also exhibits thermotropic liquid crystalline property revealing a columnar phase.

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Effect of a polymer network on the threshold voltage of the Fréedericksz transition, Frank elastic constants, switching speed, and the rotational viscosity are investigated in a polymer-stabilized bent-core nematic liquid crystal with different polymer concentrations. These polymer networks form virtual surfaces with a finite anchoring energy. The studies bring out several differences in comparison to similar studies with a calamitic liquid crystal as the nematic host.

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Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. L-Asparagine (L-Asn) and L-glutamine (L-Gln) deamination plays crucial role in ALL treatment. Role of Erwinaze (L-asparaginase from Erwinia chrysanthemi) in regulation of L-Asn and L-Gln has been confirmed by the experimental studies.

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