Spectral signatures of intramolecular charge transfer process in beta-enaminones: a combined experimental and theoretical analysis.

In this paper, we present spectroscopic signatures of intramolecular charge transfer (ICT) and effects of solvent on the ICT process in 3-(phenylamino)-2-cyclohexen-1-one (PACO), a member of the well-known molecular family, the beta-enaminones. The dual fluorescence in the steady state emission spectra of the molecule in polar solvents indicates the occurrence of ICT, which is further supported by time-resolved studies, using time correlated single photon counting technique with picosecond resolution. To understand the nature of the charge transfer, pH dependent studies of the probe in water were performed, where a quenching of fluorescence was observed even in the presence of very low concentrations of acids.

Nanopools governing proton transfer in diametrical ways in the ground and excited state.

We present here the effects of geometrically constrained environments on the proton transfer reaction of 4-methyl 2,6-diformyl phenol (MFOH) both in the ground and excited states by employing steady-state and time-resolved fluorescence spectroscopy having picosecond and femtosecond resolutions. The nanometer-sized water pools formed in the ternary microemulsion of n-heptane-aerosol OT-water promote reprotonation of the probe. As we go on increasing the water content up to a certain value in the ground state whereas deprotonation is favored in the excited state.

Proton-transfer reaction of 4-methyl 2,6-diformyl phenol in cyclodextrin nanocage.

We report here on the steady-state and time-resolved fluorescence studies on proton-transfer (PT) reaction of 4-methyl 2,6-diformyl phenol (MFOH) in confined nanocavities in three solvents, dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), and water. Though DMSO and DMF individually interact with MFOH in a similar fashion, their modes of interaction get significantly modified in the presence of cyclodextrin (CD) nanocages. In DMSO, in the ground state, the solvated molecular anion of MFOH forms 1:1 inclusion complex with beta- or gamma-CD and attains greater stability compared to the normal form.

Surgical management of metastatic melanoma to the ventricle.

The treatment of patients who have cardiac tumors can be challenging, because these tumors occur infrequently and in variable locations, and surgical resection is often technically difficult. We report the cases of 2 patients, each of whom underwent successful surgical excision of large melanomas that had metastasized to the right cardiac ventricle. Although the presence of widespread disease and a limited life expectancy usually prevent surgical therapy for patients who have metastatic cardiac tumors, removal of such masses greatly facilitated subsequent medical management of these 2 patients and improved their quality of life.