Publications by authors named "Madhuri M Rudolph"
MRI-targeted biopsy cores from prostate index lesions: assessment and prediction of the number needed.
Prostate Cancer Prostatic Dis
September 2023
Article Synopsis
- MRI is crucial for detecting prostate lesions before a targeted biopsy, but it's still unclear how many biopsy cores from the lesion are necessary for an accurate diagnosis.
- A study analyzed data from 451 patients who underwent MRI-targeted biopsies, focusing on the number of cores needed and developing a prediction model for diagnosis accuracy.
- The findings revealed that 97% of relevant diagnoses were made after obtaining three biopsy cores, while a prediction model achieved an accuracy of 79%, suggesting that collecting at least three cores is essential for effective identification of significant lesions.
Article Synopsis
- The study investigates the differences in inter-reader variability when using the PI-RADS v2 and v2.1 for classifying prostate lesions through multiparametric MRI.
- Results show that PI-RADS v2.1 has better agreement among radiologists in the peripheral zone but lower in the transition zone.
- Combining scores 1 and 2 in PI-RADS v2.1 led to nearly perfect agreement in the peripheral zone and substantial agreement in the transition zone, suggesting a need for clearer definitions in these scoring categories.
The purpose of this study is to compare diagnostic performance of Prostate Imaging Reporting and Data System (PI-RADS) version (v) 2.1 and 2.0 for detection of Gleason Score (GS) ≥ 7 prostate cancer on MRI.
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- The study aimed to evaluate if MRI size cut-offs can effectively identify clinically significant prostate cancer (csPCA), focusing on improving existing criteria in PI-RADS.
- MRIs from 293 patients were analyzed, with tumors measured from different zones and correlated with their Gleason grades; 309 lesions were examined.
- Results indicated that lesion size has a stronger association with clinically significant cancer in the peripheral zone (PZ) than in the transition zone (TZ), suggesting size cut-offs of 14 mm for PZ and 21 mm for TZ to better differentiate between cancer severities.
Objectives: To assess the discriminatory power of lexicon terms used in PI-RADS version 2 to describe MRI features of prostate lesions.
Methods: Four hundred fifty-four patients were included in this retrospective, institutional review board-approved study. Patients received multiparametric (mp) MRI and subsequent prostate biopsy including MRI/transrectal ultrasound fusion biopsy and 10-core systematic biopsy.