Production of Extracellular Matrix Proteins in the Cytoplasm of : Making Giants in Tiny Factories.

is the most widely used protein production host in academia and a major host for industrial protein production. However, recombinant production of eukaryotic proteins in prokaryotes has challenges. One of these is post-translational modifications, including native disulfide bond formation.

Formulation and evaluation of floating, pulsatile, multiparticulates using pH-dependent swellable polymers.

The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release, i.e.