Context: The smear layer may harbor many bacteria; hence, alternative methods are used to disrupt and remove biofilm.
Aim: The aim of the study was to compare the effectiveness of EndoActivator, PATS Vario System, and XP-endo Finisher files on smear layer removal using a scanning electron microscope.
Subjects And Methods: Sixty single-rooted extracted premolars with Vertucci Type 1 configuration were decoronated and divided into four groups.