Minimally invasive procedures for the recognition and diagnosis of oral precancer and cancer.

Oral cancer represents a blend of genetic and epigenetic instability. Many a times, oral cancer occurs in the background of oral potentially malignant disorders (OPMDs), which could be easily detected and diagnosed. Various diagnostic aids have been explored for early detection of oral cancer.

Advanced diagnostic aids for oral cancer.

Oral cancer, a universal malady, has become a stumbling block over the years due to its significant morbidity and mortality rates. The greater morbidity associated with this deadly disease is attributed to delay in its diagnosis / its presentation in advanced stage. Being multifactorial, Oral squamous cell carcinoma (OSCC) is the outcome of genetic and epigenetic instability.

Intra-observer and inter-observer variability in two grading systems for oral epithelial dysplasia: A multi-centre study in India.

Background: The presence and grading of oral epithelial dysplasia (OED) are considered the gold standard for predicting the malignant risk of oral potentially malignant disorders. However, inter-observer and intra-observer agreement in the context of reporting on OED grading has been reputedly considered unreliable.

Methods: We undertook a multi-centre study of six Indian oral pathologists to assess variations in reporting OED using the World Health Organization (WHO; 2005) system and also the recently introduced binary system.

Detection of salivary heat shock protein 27 by enzyme-linked immunosorbent assay and its correlation with histopathology of oral leukoplakia.

Context: Salivary analytes may be used as biomarkers for translational and clinical applications. Heat shock proteins (Hsps) are ubiquitous, highly conserved proteins found in all prokaryotic and eukaryotic species. Hsp27, a low molecular weight protein, may act as a salivary biomarker.

Role of tissue eosinophils in oral Leukoplakia: A pilot study.

Context: Tissue eosinophilia in oral squamous cell carcinoma has been well - recognized. Studies have reported both favorable and unfavorable prognoses associated with tissue eosinophils in oral squamous cell carcinoma. However, the role of eosinophils in the development of tumor is still unclear.

Lichenoid Features and Fibrosis: Coexistence in Quid-induced Oral Lesions.

Background: Oral submucous fibrosis (OSF) and quid associated oral lichenoid lesions (QOLL) are caused because of areca nut chewing and both show very characteristic histological changes. The present study aims to determine the histopathological presence of lichenoid features in cases of OSF as well as to determine the presence of fibrosis in cases of QOLL.

Materials And Methods: The study involved the retrospective analysis of hematoxylin and eosin stained slides of OSF (n = 50) and QOLL (n = 16).

Effect of Different Phases of Menstrual Cycle on Reflection Index, Stiffness index and Pulse wave velocity in Healthy subjects.

Introduction: Arterial compliance will result in stabilizing the fluctuations in arterial pressure and blood flow. So arterial stiffness can be a good indicator for monitoring the cardiovascular system. Arterial stiffness can be measured using indices like reflection index (RI), stiffness index (SI) and Brachial Finger Pulse Wave Velocity (BFPWV).

Effect of short duration aerobic exercise training on reflection index, stiffness index and pulse wave velocity.

The study was aimed to establish the effect of aerobic exercise on reflection index (RI), stiffness index (SI) and brachial finger pulse wave velocity (BFPWV) in healthy subjects of Bangalore, India. Students of 18 to 25 years (males) were recruited according to the inclusion criteria. The subjects were trained on treadmill for a period of 8 weeks, and the above parameters were measured using BIOPAC software and doppler machine.