Exploring an interesting dual functionality of anacardic acid for efficient paclitaxel delivery in breast cancer therapy.

Aim: To explore the potential of paclitaxel (PTX)-loaded anacardic acid conjugated hydrophobized gelatin nanoparticles.

Materials & Methods: Nanoparticles prepared by nanoprecipitation technique were evaluated for various quality attributes (particle size, % entrapment efficiency) in vitro drug release, MCF-7 cell uptake, cell cytotoxicity, in vivo pharmacokinetics, antitumor efficacy and toxicity.

Results: The nanoparticles (250-300 nm, 74% entrapment efficiency) showed approximately 2.