The synergistic anti-Warburg efficacy of temozolomide, metformin and epigallocatechin gallate in glioblastoma.

An important hallmark of glioblastoma aggressiveness is its altered metabolism of glucose. This metabolic shift wherein the tumor cells employ aerobic glycolysis regardless of oxygen availability via reprogramming of mitochondrial oxidative phosphorylation is known as the Warburg effect. Previous literatures have linked this metabolic reprograming to tumor progression and glioblastoma cell proliferation making it a key target for targeted drug therapy.

Corrigendum: A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy .

[This corrects the article DOI: 10.3389/fphar.2023.

A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy .

Glioma is the most devastating high-grade tumor of the central nervous system, with dismal prognosis. Existing treatment modality does not provide substantial benefit to patients and demands novel strategies. One of the first-line treatments for glioma, temozolomide, provides marginal benefit to glioma patients.