Publications by authors named "Madhu S Nair"

Colorectal cancer ranks as the second most prevalent cancer worldwide, with a high mortality rate. Colonoscopy stands as the preferred procedure for diagnosing colorectal cancer. Detecting polyps at an early stage is critical for effective prevention and diagnosis.

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Revolutionary advances in DNA sequencing technologies fundamentally change the nature of genomics. Today's sequencing technologies have opened into an outburst in genomic data volume. These data can be used in various applications where long-term storage and analysis of genomic sequence data are required.

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Several infectious diseases have affected the lives of many people and have caused great dilemmas all over the world. COVID-19 was declared a pandemic caused by a newly discovered virus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by the World Health Organisation in 2019. RT-PCR is considered the golden standard for COVID-19 detection.

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Nuclear atypia scoring (NAS), forms a significant factor in determining individualized treatment plans and also for the prognosis of the disease. Automation of cancer grading using quantitative image-based analysis of histopathological images can circumvent the shortcomings of the prevailing manual grading and can assist the pathologists in cancer diagnosis. However, developing such a robust classifier model require sufficient amount of annotated data, while the labeled histopathological images are scarce and expensive to procure as annotation forms a time-consuming and laborious task.

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Corona Virus Disease-2019 (COVID-19) is a global pandemic which is spreading briskly across the globe. The gold standard for the diagnosis of COVID-19 is viral nucleic acid detection with real-time polymerase chain reaction (RT-PCR). However, the sensitivity of RT-PCR in the diagnosis of early-stage COVID-19 is less.

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Corona virus disease-2019 (COVID-19) is a pandemic caused by novel coronavirus. COVID-19 is spreading rapidly throughout the world. The gold standard for diagnosing COVID-19 is reverse transcription-polymerase chain reaction (RT-PCR) test.

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Breast cancer is the most prevalent invasive type of cancer among women. The mortality rate of the disease can be reduced considerably through timely prognosis and felicitous treatment planning, by utilizing the computer aided detection and diagnosis techniques. With the advent of whole slide image (WSI) scanners for digitizing the histopathological tissue samples, there is a drastic increase in the availability of digital histopathological images.

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Breast cancer is the most common type of malignancy diagnosed in women. Through early detection and diagnosis, there is a great chance of recovery and thereby reduce the mortality rate. Many preliminary tests like non-invasive radiological diagnosis using ultrasound, mammography, and MRI are widely used for the diagnosis of breast cancer.

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Video summarization aims to find a compact representation of input videos. The method finds out interesting parts of the video by discarding the remaining parts of the video. The abstracts thus generated enhances browsing and retrieval of video data.

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Breast cancer is found to be the most pervasive type of cancer among women. Computer aided detection and diagnosis of cancer at the initial stages can increase the chances of recovery and thus reduce the mortality rate through timely prognosis and adequate treatment planning. The nuclear atypia scoring or histopathological breast tumor grading remains to be a challenging problem due to the various artifacts and variabilities introduced during slide preparation and also because of the complexity in the structure of the underlying tissue patterns.

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A novel method to determine the Grade Group (GG) in prostate cancer (PCa) using multi-parametric magnetic resonance imaging (mpMRI) biomarkers is investigated in this paper. In this method, high-level features are extracted from hand-crafted texture features using a deep network of stacked sparse autoencoders (SSAE) and classified them using a softmax classifier (SMC). Transaxial T2 Weighted (T2W), Apparent Diffusion Coefficient (ADC) and high B-Value Diffusion-Weighted (BVAL) images obtained from PROSTATEx-2 2017 challenge dataset are used in this technique.

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Mitotic count is an important diagnostic factor in breast cancer grading and prognosis. Detection of mitosis in breast histopathology images is very challenging mainly due to diffused intensities along object boundary and shape variation in different stages of mitosis. This paper demonstrates an accurate technique for detecting the mitotic cells in Hematoxyline and Eosin stained images by step by step refinement of segmentation and classification stages.

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The exact measure of mitotic nuclei is a crucial parameter in breast cancer grading and prognosis. This can be achieved by improving the mitotic detection accuracy by careful design of segmentation and classification techniques. In this paper, segmentation of nuclei from breast histopathology images are carried out by Localized Active Contour Model (LACM) utilizing bio-inspired optimization techniques in the detection stage, in order to handle diffused intensities present along object boundaries.

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