Atypical presentations of amyotrophic lateral sclerosis: a case report.

Amyotrophic lateral sclerosis (ALS) with atypical symptoms poses a diagnostic challenge to clinicians, frequently resulting in delayed diagnosis. The patient reported here presented with unexplained weight loss and was investigated for 8 months, with an extensive work-up, including several imaging studies, especially to rule out neoplastic processes, before a diagnosis of ALS could be made, largely on the basis of upper and lower motor weakness.

Osteosarcoma with cutaneous metastases. A case report.

Background: Osteosarcomas, despite their aggressive nature and propensity to metastasize, only rarely give rise to skin deposits.

Case: We report a case of a femoral osteosarcoma in which cutaneous scalp and neck metastases developed 3 years after treatment of the primary disease. Fine needle aspiration was pivotal in diagnosing the secondary disease.