A dual-band reflective polarizer based meta-surface with higher angular stability for C and X-band applications.

A reflective dual-band linear-to-circular polarizer for C and X-band application is presented. The proposed elliptical Frequency Selective Surface (FSS) is capable of enhancing the polarization control and minimizes the cross-polarization compared to traditional circular or square geometries. The linear-to-circular polarization is achieved through two elliptical apertures, where each shape generates orthogonal modes with a 90° phase shift.

Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma.

Unlabelled: Pancreatic ductal adenocarcinoma (PDAC) is an insidious disease with a low 5-year survival rate. PDAC is characterized by infiltration of abundant tumor-associated macrophages (TAM), which promote immune tolerance and immunotherapeutic resistance. Here we report that macrophage spleen tyrosine kinase (Syk) promotes PDAC growth and metastasis.

Inhibition of biofilm formation, quorum sensing and virulence factor production in Pseudomonas aeruginosa PAO1 by selected LasR inhibitors.

The quorum sensing network of Pseudomonas aeruginosa mediates the regulation of genes controlling biofilm formation and virulence factors. The rise of drug resistance to Pseudomonas aeruginosa infections has made quorum sensing-regulated biofilm formation in clinical settings a major issue. In the present study, LasR inhibitors identified in our previous study were evaluated for their antibiofilm and antiquorum sensing activities against P.

Harnessing Demographic Dividend Before it is Lost Forever in India.

Based on the secondary data taken from Population Census, and the Employment-Unemployment Surveys and Periodic Labour Force Survey of the National Sample Survey, it is found that Indian economy is passing through a critical phase of economic development in which it is likely to lose its demographic advantage. Because, in India while about 4.5 million people were leaving agriculture every year prior to the Covid-19 pandemic years, the non-farm sectors job was not growing adequately to accommodate the persons leaving agriculture, and the newly educated non-farm job seekers.

Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers.

Background: Cutaneous malignancies most commonly arise from skin epidermal cells. These cancers may rapidly progress from benign to a metastatic phase. Surgical resection represents the gold standard therapeutic treatment of non-metastatic skin cancer while chemo- and/or radiotherapy are often used against metastatic tumors.

Microarray and pattern miner analysis of AXL and VIM gene networks in MDA‑MB‑231 cells.

MDA‑MB‑231 cells represent malignant triple‑negative breast cancer, which overexpress epidermal growth factor receptor (EGFR) and two genes (AXL and VIM) associated with poor prognosis. The present study aimed to identify novel therapeutic targets and elucidate the functional networks for the AXL and VIM genes in MDA‑MB‑231 cells. We identified 71 genes upregulated in MDA‑MB‑231 vs.

Human Granzyme B Based Targeted Cytolytic Fusion Proteins.

Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or enzymes has been shown to promote the induction of apoptosis in cancerous cells. The 4th generation of targeted effectors are being designed to be as humanized as possible—a solution to the problem of immunogenicity encountered with existing generations.