Statistical optimization and in vitro evaluation of metformin hydrochloride asymmetric membrane capsules prepared by a novel semiautomatic manufacturing approach.

Asymmetric membrane capsules (AMCs) are one of the novel osmotic delivery devices which deliver a wide range of drugs in controlled manner. In the present work, we developed and validated a semiautomatic process by fabricating a hydraulic assisted bench top model for manufacturing AMCs. The capsule walls of AMCs were prepared by dip coating phase inversion process using cellulose acetate butyrate (CAB) as coating polymer and propylene glycol (PG) as plasticizer and pore former.

Information is not lost in the evaporation of 2D black holes.

We analyze Hawking evaporation of the Callan-Giddings-Harvey-Strominger black holes from a quantum geometry perspective and show that information is not lost, primarily because the quantum space-time is sufficiently larger than the classical. Using suitable approximations to extract physics from quantum space-times we establish that (i) the future null infinity of the quantum space-time is sufficiently long for the past vacuum to evolve to a pure state in the future, (ii) this state has a finite norm in the future Fock space, and (iii) all the information comes out at future infinity; there are no remnants.