Effects of sodium hyaluronate and methylprednisolone alone or in combination in preventing epidural fibrosis.

Objective: Epidural fibrosis and leptomeningeal adhesion formation are common causes of failed back surgery syndrome (FBSS). We employed a rat model of lumbar laminectomy to evaluate the histopathological effects of sodium hyaluronate (HA) and methylprednisolone (MP) alone or in combination on post-laminectomy epidural fibrosis.

Methods: Thirty-two male Sprague-Dawley rats were divided into four groups.