Publications by authors named "Madelyn R Kenny"
Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease.
Invest Ophthalmol Vis Sci
May 2024
Article Synopsis
- - The study investigates the role of neuroinflammation in Alzheimer's disease (AD), specifically looking at retinal glial activation in mouse models and human biopsies, hypothesizing increased retinal gliosis in preclinical AD patients compared to controls.
- - Using optical coherence tomography (OCT), researchers analyzed images from 76 participants, including 22 with preclinical AD and 20 healthy controls, focusing on the surface area of retinal gliosis and retinal nerve fiber layer (RNFL) thickness.
- - Results indicated significantly greater retinal gliosis in the preclinical AD group compared to controls, suggesting that this retinal change could serve as a potential biomarker for neuroinflammation associated with Alzheimer's disease.