Publications by authors named "Madelyn Green"

Article Synopsis
  • The amino acid isoleucine plays a significant role in metabolic health, with lower dietary levels linked to improved health in mice on a Western Diet.
  • The effects of isoleucine reduction vary by sex and strain in mice, showing a protective benefit against metabolic issues, while its increase can worsen health.
  • Findings reveal that a core molecular response to dietary isoleucine exists across different sexes and strains, highlighting its potential as a dietary strategy for better metabolic health in humans.
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Low-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we examine this paradox using weight pulling, a validated progressive resistance exercise training regimen, in mice fed either an LP diet or an isocaloric HP diet.

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Objectives: The southern Brazilian shellmounds provide archaeological evidence of prolonged human activity in the coast from approximately 6000 to 1000 BP. Shellmound building populations exploited the rich coastal estuarine zones, and the human remains recovered from them are important sources of information on health and overall lifestyle of these mid-Holocene groups. Therefore, they were included in the Western Hemisphere Global History of Health project.

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MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively.

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