Publications by authors named "Madelyn E Hicks"
Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss.
Edward J Dougherty Li-Yuan Chen Keytam S Awad Gabriela A Ferreyra Cumhur Y Demirkale Madelyn E Hicks
Am J Physiol Lung Cell Mol Physiol
June 2023
Article Synopsis
- * Silencing NR2F2 in human endothelial cells causes inflammation, increased cell migration, resistance to apoptosis, and changes related to vascular damage, while also elevating DKK1 levels, which is associated with pulmonary arterial hypertension.
- * Therapeutic strategies that either activate NR2F2 or block DKK1 might offer potential treatments for chronic vascular diseases linked to endothelial cell dysfunction.