Publications by authors named "Madelyn Auvinen"
Angiotensin-converting enzyme 2 (ACE2) and transmembrane proteases (TMPRSS) are multifunctional proteins required for SARS-CoV-2 infection or for amino acid (AA) transport, and are abundantly expressed in mammalian small intestine, but the identity of the intestinal cell type(s) and sites of expression are unclear. Here we determined expression of SARS-CoV-2 entry factors in different cell types and then compared it to that of representative AA, electrolyte, and mineral transporters. We tested the hypothesis that SARS-CoV-2, AA, electrolyte, and mineral transporters are expressed heterogeneously in different intestinal cell types by making mouse enteroids enriched in enterocytes (ENT), goblet (GOB), Paneth (PAN), or stem (ISC) cells.
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- High fructose intake is linked to metabolic diseases, particularly affecting lipid metabolism in the small intestine, but the specific cell types involved remained unclear.
- The study investigated how fructose influences the expression of lipid-related genes, focusing on the role of the fructose transporter Slc2a5 and ketohexokinase, assuming this effect occurs primarily in enterocytes.
- Results showed that enterocytes increased lipogenic gene expression significantly in response to fructose, while this effect was not observed in mice lacking Slc2a5 or Khk, indicating these components are crucial for the process.