Publications by authors named "Madelon Badoux"
Article Synopsis
- * Researchers created models using mice to study 115 cases of DCIS, helping them discover important signs that can indicate whether a case is high-risk.
- * The study found that certain traits in DCIS, like being high grade or having specific genetic changes, suggest a higher chance of becoming invasive cancer, and they built a collection of 19 models for further research.
Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However, clinical responses to FGFR inhibitors have remained variable, emphasizing the need to better understand which FGFR2 alterations are oncogenic and therapeutically targetable. Here we apply transposon-based screening and tumour modelling in mice, and find that the truncation of exon 18 (E18) of Fgfr2 is a potent driver mutation.
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